Existen diversas causas y se pueden dividir en factores generales y locales.
Desde el punto de vista local, la causa más frecuente es la falta de espacio (como son los últimos en salir, generalmente «llegan tarde a la repartición de hueso»).Otras causas locales son: mala posición de la muela, aparición de dientes supernumerarios (dientes extras), quistes y tumores vecinos al germen del tercer molar.
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